Ivacaftor for Cystic Fibrosis
Molecular visualization in a 2-page spread
Cystic Fibrosis is a serious genetic disease that causes deficits in fluid transport of epithelial cells. It's characterized by the sticky mucus in lung and multiple organ dysfunction. In 2012, Ivacaftor was approved by U.S. Food and Drug Administration (FDA). It is the very first drug to treat the cause of cystic fibrosis and it was granted the first Breakthrough Therapy designation to cystic fibrosis by FDA. This 2-page spread takes a deep dive into the disease pathogenesis and visualize how the therapy works in a bimolecular scale.
VMD, 3D Protein Imager, Autodesk Maya, and Adobe Illustrator
Final presentation format
A two page spread in a scientific magazine
The general public with a science background
Ideation and Reference
Draft layout with preliminary research to block in places for text and illustrations.
PBD ID: 6MSM, 5UAK, and 6O2P
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Liu, F., Zhang, Z., Csanády, L., Gadsby, D. C., & Chen, J. (2017). Molecular Structure of the Human CFTR Ion Channel. Cell, 169(1), 85–95.e8. https://doi.org/10.1016/j.cell.2017.02.024
Liu, F., Zhang, Z., Levit, A., Levring, J., Touhara, K. K., Shoichet, B. K., & Chen, J. (2019). Structural identification of a hotspot on CFTR for potentiation. Science, 364(6446), 1184–1188. https://doi.org/10.1126/science.aaw7611
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National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 16220172, Ivacaftor. Retrieved July 16, 2021 from https://pubchem.ncbi.nlm.nih.gov/compound/Ivacaftor.
Cystic Fibrosis | NHLBI, NIH. (2021, May 12). National Heart, Lung and Blood Institute. https://www.nhlbi.nih.gov/health-topics/cystic-fibrosis